Tumor necrosis factor: receptors on hematopoietic cells

Tumor necrosis factor: receptors on hematopoietic cells.

Tumor necrosis factor (TNF) is a monokine that is cytotoxic/cytostatic for a variety of tumor cells and has multiple effects on normal cells. We demonstrate that normal and malignant human myeloid cells express a single class of high-affinity receptors (400 to 1,900 per cell, KD 20 to 90 pmol/L) for TNF. Mitogen-stimulated lymphocytes have a similar number of TNF receptors, whereas resting lymp...

Expression of Tumor Necrosis Factor Receptors

Kuzell Institute for Arthritis and Infectious Diseases, Medical Research Institute of San Francisco at California Pacific Medical Center, 2200 Webster Street, Suite 305, San Francisco, California 941151U Department ofImmunology and Infectious Diseases, Research Institute, Palo Alto Medical Foundation, Palo Alto, California 943012; and Division of Infectious Diseases, Stanford University School ...

Tumor necrosis factor restricts hematopoietic stem cell activity in mice: involvement of two distinct receptors

Whereas maintenance of hematopoietic stem cells (HSCs) is a requisite for life, uncontrolled expansion of HSCs might enhance the propensity for leukemic transformation. Accordingly, HSC numbers are tightly regulated. The identification of physical cellular HSC niches has underscored the importance of extrinsic regulators of HSC homeostasis. However, whereas extrinsic positive regulators of HSCs...

CIRCULATING SOLUBLE TUMOR NECROSIS FACTOR RECEPTORS, INTERLEUKIN-2 RECEPTORS, TUMOR NECROSIS FACTOR a, AND INTERLEUKIN-6 LEVELS IN RHEUMATOID ARTHRITIS

Functional activities of receptors for tumor necrosis factor-alpha on human vascular endothelial cells.

Tumor necrosis factor-alpha (TNF-alpha) plays a critical role in the control of endothelial cell function and hence in regulating traffic of circulating cells into tissues in vivo. Stimulation of endothelial cells in vitro by TNF-alpha increases the surface expression of leukocyte adhesion molecules, enhances cytokine production, and induces tissue factor procoagulant activity. In the present s...